While there are no known contraindications for melatonin and pregnancy, there also aren’t enough studies on the use of melatonin during pregnancy, particularly long-term studies, to conclusively say whether it’s safe or not. This is often the case when it comes to studies about therapeutic treatments and pregnancy, given the sensitive nature of such studies. Most of the research done thus far comes from animal studies, which have shown positive results.
The placenta produces melatonin and this source of melatonin is thought to be important to maintaining a normal, healthy pregnancy. In animal studies, it has been shown that supplementation with melatonin decreases the risk of pre-eclampsia, preterm birth and intrauterine growth retardation (IUGR).
Studies of melatonin in humans with IUGR and pre-eclampsia are now in their earliest phases. Preliminary studies also suggest that melatonin supplementation may have a beneficial effect on fertilization rates and embryo quality, likely due to a reduction in oxidative damage. Animal studies have also demonstrated the importance of melatonin in fetal development. During pregnancy, night-time concentrations of melatonin increase steadily after 24 weeks of gestation. Melatonin receptors are present throughout the developing fetus from the earliest stages. There is solid evidence that melatonin is neuroprotective and plays an important role in training circadian rhythms in the developing fetus; however, melatonin may have other important actions for the fetus outside of the brain.
All Mella are formulated to be effective yet gentle, nontoxic, and safe. All of our formulas have successfully passed HRIPT, which is conducted on adults. When it comes to pregnancy and breastfeeding, we always recommend showing our ingredient lists to your doctor to confirm safety for you specifically!